Correct Answer- C Brexanolone
Explanation:
This postpartum depression patient is suffering from hot flashes as a side effect from the Brexanolone (choice C). Hot flashes are defined as fleeting sensations of heat, sweating, flushing, anxiety, and chills that last 1-5 minutes. Brexanolone is an aqueous formulation of allopregnanolone whose mechanism of action is not fully known. The most common side effects are somnolence, dizziness, loss of consciousness, xerostomia, and hot flashes. Paroxetine (choice A) is a SSRI and Venlafaxine (choice B) is a SNRI that are both used for the treatment of hot flashes. Amitriptyline (choice D) is a tricyclic antidepressant that inhibits the reuptake of serotonin and norepinephrine. Its most common side effects are orthostatic hypotension, prolonged QT interval, respiratory depression, hyperpyrexia, tremors, and anticholinergic symptoms (e.g. urinary retention and confusion). Tadalafil (choice E) is a phosphodiesterase type 5 inhibitor that is used for erectile dysfunction, pulmonary hypertension, and benign prostatic hyperplasia. It may cause hot flashes, but it is not used for treating depression.
REF:
1-Azhar Y, Din AU. Brexanolone. [Updated 2020 Jun 22]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing
2-Bansal, R., & Aggarwal, N. (2019). Menopausal hot flashes: a concise review. Journal of mid-life health, 10(1), 6.